'Velcro' structure can help repair the damaged heart

by:BAILI     2020-10-30
Canadian engineering personnel to the latest development of a biological compatibility, can be like 'hook and loop' to 'button' into heart cells together, so that the assembly of functional heart tissue becomes like a shoe buckle. Participate in the research of chemical engineering, university of Toronto, Dr Aoj the description to the journal of science and technology press, according to the heart by many strip myocardial fibers woven, 'if a single fiber as a one-dimensional structure, ( Repair the damaged heart) The second step is to create a 2 d structure, then assemble them into a three-dimensional structure. 'Two years ago, jaco the team had invented the' life line '( Biowire) To imitate growth way in heart muscle fibres. The latest study is the 'life line' technology from one dimensional space is extended to 3 d space. They use a special polymer POMaC create a two-dimensional grid of available for cell growth. The grid can be loaded into a kind of honeycomb, but the hole is not symmetrical, on one side than the other side to be more wide. This grid structure to cell provides a 'blouses sit' template. When using current stimulation, myocardial cell will shrink together, leading to a flexible polymer bent. Team are published in the latest issue of the journal science progress that will T 'pillars' binding on honeycomb, when the second layer overlay on it, the 'pillars' will be like small hooks, through the honeycomb holes buckle knot in place. This is like hook and loop ( Fastening belt) The plastic on the hook and loop, design inspiration from the plant for the seed sticks on animals and generate hooked spines. The advantages of this technology in three aspects: 'Velcro' structure makes the myocardial tissue more rapid assembly; Allows cells aggregate into myocardial tissue for strip fiber, superposition of several layers of grid similar to the spring, the cells on the scalable to beat; Optional assembly and disassembly of the function can be used in many research fields. This technology will eventually be used to create can repair the damaged heart tissue, its modular nature can make it easier for custom grafts for the patient. These tiny module or can build a future surgery needed any size of the organization, and a biodegradable polymer scaffold itself, will gradually break down and be absorbed by human body in just a few months.
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